Description
Antibody Name: | B4GALNT2 Antibody (PACO39962) |
Antibody SKU: | PACO39962 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Beta-1,4 N-acetylgalactosaminyltransferase 2 protein (301-566AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO39962 at dilution of 1:100. |
Background: | Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. |
Synonyms: | Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-) (Sd(a) beta-1,4-GalNAc transferase) (UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase), B4GALNT2, GALGT2 |
UniProt Protein Function: | Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. |
UniProt Protein Details: | |
NCBI Summary: | B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q8NHY0 |
NCBI GenInfo Identifier: | 227498224 |
NCBI Gene ID: | 124872 |
NCBI Accession: | NP_001152859.1 |
UniProt Secondary Accession: | Q8NHY0,Q14CP1, Q86Y40, B4DZE4 |
UniProt Related Accession: | Q8NHY0 |
Molecular Weight: | 62 |
NCBI Full Name: | beta-1,4 N-acetylgalactosaminyltransferase 2 isoform b |
NCBI Synonym Full Names: | beta-1,4-N-acetyl-galactosaminyltransferase 2 |
NCBI Official Symbol: | B4GALNT2 |
NCBI Official Synonym Symbols: | B4GALT; GALGT2 |
NCBI Protein Information: | beta-1,4 N-acetylgalactosaminyltransferase 2 |
UniProt Protein Name: | Beta-1,4 N-acetylgalactosaminyltransferase 2 |
UniProt Synonym Protein Names: | Sd(a) beta-1,4-GalNAc transferase; UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase |
Protein Family: | |
UniProt Gene Name: | B4GALNT2 |
UniProt Entry Name: |