Axl Monoclonal Antibody (CAB22378)
- SKU:
- CAB22378
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Axl Monoclonal Antibody |
| Product Code: | CAB22378 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53006 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, Mouse heart |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-449 of human Axl (NP_068713.2). |
| Sequence: | EESPF VGNPG NITGA RGLTG TLRCQ LQVQG EPPEV HWLRD GQILE LADST QTQVP LGEDE QDDWI VVSQL RITSL QLSDT GQYQC LVFLG HQTFV SQPGY VGLEG LPYFL EEPED RTVAA NTPFN LSCQA QGPPE PVDLL WLQDA VPLAT APGHG PQRSL HVPGL NKTSS FSCEA HNAKG VTTSR TATIT VLPQQ PRNLH LVSRQ PTELE VAWTP GLSGI YPLTH CTLQA VLSDD GMGIQ AGEPD PPEEP LTSQA SVPPH QLRLG SLHPH TPYHI RVACT SSQGP SSWTH WLPVE TPEGV PLGPP ENISA TRNGS QAFVH WQEPR APLQG TLLGY RLAYQ GQDTP EVLMD IGLRQ EVTLE LQGDG SVSNL TVCVA AYTAA GDGPW SLPVP LEAWR PGQAQ PVHQL VKEPS TPAFS WP |
| Synonyms: | ARK, UFO, JTK11, Tyro7 |
| Calculated MW: | 98kDa |
| Observed MW: | 138kDa |
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