AURKAIP1 Antibody (PACO15813)
- SKU:
- PACO15813
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | AURKAIP1 Antibody (PACO15813) |
| Antibody SKU: | PACO15813 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human AURKAIP1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO15813(AURKAIP1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid, protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinsons disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |
| Synonyms: | aurora kinase A interacting protein 1 |
| UniProt Protein Function: | AKIP: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 1p36.33Cellular Component: nucleoplasm; mitochondrion; intracellular membrane-bound organelle; mitochondrial inner membrane; nucleusMolecular Function: protein bindingBiological Process: mitochondrial translation; positive regulation of proteolysis; organelle organization and biogenesis; negative regulation of mitosis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9NWT8 |
| NCBI GenInfo Identifier: | 34783645 |
| NCBI Gene ID: | 54998 |
| NCBI Accession: | BC062333 |
| UniProt Secondary Accession: | Q9NWT8,Q5TA36, Q8TBD3 |
| UniProt Related Accession: | Q9NWT8 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | AURKAIP1 protein, partial |
| NCBI Synonym Full Names: | aurora kinase A interacting protein 1 |
| NCBI Official Symbol: | AURKAIP1 |
| NCBI Official Synonym Symbols: | AIP; AKIP; MRP-S38 |
| NCBI Protein Information: | aurora kinase A-interacting protein; 28S ribosomal protein S38, mitochondrial; AURKA-interacting protein; aurora-A kinase interacting protein |
| UniProt Protein Name: | Aurora kinase A-interacting protein |
| UniProt Synonym Protein Names: | 28S ribosomal protein S38, mitochondrial; MRP-S38 |
| Protein Family: | Aurora kinase A-interacting protein |
| UniProt Gene Name: | AURKAIP1 |
| UniProt Entry Name: | AKIP_HUMAN |
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