ATXN1L Antibody (PACO48246)
- SKU:
- PACO48246
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ATXN1L Antibody (PACO48246) |
| Antibody SKU: | PACO48246 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Ataxin-1-like protein (183-463AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO48246 at dilution of 1:100. |
| Background: | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity). |
| Synonyms: | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1), ATXN1L, BOAT BOAT1 |
| UniProt Protein Function: | ataxin-1L: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). Belongs to the ATXN1 family.Chromosomal Location of Human Ortholog: 16q22.2Cellular Component: nucleolus; nucleoplasm; nucleusMolecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P0C7T5 |
| NCBI GenInfo Identifier: | 206557834 |
| NCBI Gene ID: | 342371 |
| NCBI Accession: | P0C7T5.1 |
| UniProt Secondary Accession: | P0C7T5 |
| UniProt Related Accession: | P0C7T5 |
| Molecular Weight: | 73,306 Da |
| NCBI Full Name: | Ataxin-1-like |
| NCBI Synonym Full Names: | ataxin 1 like |
| NCBI Official Symbol: | ATXN1L |
| NCBI Official Synonym Symbols: | BOAT; BOAT1 |
| NCBI Protein Information: | ataxin-1-like |
| UniProt Protein Name: | Ataxin-1-like |
| UniProt Synonym Protein Names: | Brother of ataxin-1; Brother of ATXN1 |
| Protein Family: | Ataxin |
| UniProt Gene Name: | ATXN1L |
| UniProt Entry Name: | ATX1L_HUMAN |
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