ATR Monoclonal Antibody (CAB22124)
- SKU:
- CAB22124
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | ATR Monoclonal Antibody |
| Product Code: | CAB22124 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53816 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293F |
| Cellular Location: | Golgi apparatus, Nucleoplasm, Nucleus, PML body |
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ATR (NP_001175.2). |
| Sequence: | LKMES MEIIE EIQCQ TQQEN LSSNS DGISP KRRRL SSSLN PSKRA PKQTE EIKHV DMNQK SILWS ALKQK AESLQ ISLEY SGLKN PVIEM LEGIA VVLQL T |
| Synonyms: | FRP1, MEC1, SCKL, FCTCS, SCKL1 |
| Calculated MW: | 301kDa |
| Observed MW: | 301kDa |
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