ATR Monoclonal Antibody (CAB21253)
- SKU:
- CAB21253
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | ATR Monoclonal Antibody |
| Product Code: | CAB21253 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC51749 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A-431, Mouse testis |
| Cellular Location: | Chromosome, Nucleus, PML body |
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2100-2200 of human ATR (NP_001175.2). |
| Sequence: | KAYEW EKAGR SDRVQ MRNDL GKINK VITEH TNYLA PYQFL TAFSQ LISRI CHSHD EVFVV LMEII AKVFL AYPQQ AMWMM TAVSK SSYPM RVNRC KEILN K |
| Synonyms: | FRP1, MEC1, SCKL, FCTCS, SCKL1 |
| Calculated MW: | 301kDa |
| Observed MW: | 301kDa |
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