| UniProt Protein Function: | ATP5S: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. Belongs to the ATP synthase subunit s family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: MitochondrialChromosomal Location of Human Ortholog: 14q21.3Cellular Component: proton-transporting ATP synthase complex, coupling factor F(o); mitochondrial inner membraneMolecular Function: metal ion binding; hydrogen ion transmembrane transporter activityBiological Process: cellular metabolic process; proton transport; mitochondrial ATP synthesis coupled proton transport |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99766 |
| NCBI GenInfo Identifier: | 51558777 |
| NCBI Gene ID: | 27109 |
| NCBI Accession: | NP_001003805.1 |
| UniProt Secondary Accession: | Q99766,Q8WWX3, Q96F77, A8K1U3, D9N156 |
| UniProt Related Accession: | Q99766 |
| Molecular Weight: | 14,667 Da |
| NCBI Full Name: | ATP synthase subunit s, mitochondrial isoform b |
| NCBI Synonym Full Names: | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) |
| NCBI Official Symbol: | ATP5S |
| NCBI Official Synonym Symbols: | FB; ATPW; HSU79253 |
| NCBI Protein Information: | ATP synthase subunit s, mitochondrial; ATP synthase-coupling factor B; ATP synthase coupling factor B-like 1; ATP synthase coupling factor B, mitochondrial; mitochondrial ATP synthase regulatory component factor B; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) |
| UniProt Protein Name: | ATP synthase subunit s, mitochondrial |
| UniProt Synonym Protein Names: | ATP synthase-coupling factor B; FB; Mitochondrial ATP synthase regulatory component factor B |
| Protein Family: | ATP synthase |
| UniProt Gene Name: | ATP5S |
| UniProt Entry Name: | ATP5S_HUMAN |
