ATG8 Antibody (PACO36682)
- SKU:
- PACO36682
Description
| Antibody Name: | ATG8 Antibody (PACO36682) |
| Antibody SKU: | PACO36682 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Candida glabrata |
| Immunogen: | Recombinant Candida glabrata Autophagy-related protein 8 protein (1-116AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. |
| Synonyms: | Autophagy-related protein 8 (Autophagy-related ubiquitin-like modifier ATG8), ATG8, AUT7 |
| UniProt Protein Function: | Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6FXR8 |
| NCBI GenInfo Identifier: | 50285085 |
| NCBI Gene ID: | 2886410 |
| NCBI Accession: | XP_444971.1 |
| UniProt Secondary Accession: | Q6FXR8 |
| UniProt Related Accession: | Q6FXR8 |
| Molecular Weight: | 13,795 Da |
| NCBI Full Name: | hypothetical protein |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | CAGL0A04675g |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | hypothetical protein |
| UniProt Protein Name: | Autophagy-related protein 8 |
| UniProt Synonym Protein Names: | Autophagy-related ubiquitin-like modifier ATG8 |
| Protein Family: | ATG8-interacting protein |
| UniProt Gene Name: | ATG8 |
| UniProt Entry Name: | ATG8_CANGA |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Fungus |
Host Species: |
Rabbit |
Isotype: |
IgG |
Applications: |
ELISA |
Antibody Type: |
Polyclonal Antibody |
Conjugation: |
Unconjugated |
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