ATG4D Polyclonal Antibody
- SKU:
- CAB21690
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | ATG4D Polyclonal Antibody |
| Product Code: | CAB21690 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:2000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Mitochondrion matrix |
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human ATG4D (NP_116274.3). |
| Sequence: | MNSVS PAAAQ YRSSS PEDAR RRPEA RRPRG PRGPD PNGLG PSGAS GPALG SPGAG PSEPD EVDKF KAKFL TAWNN VKYGW VVKSR TSFSK ISSIH LCGRR YRFEG EGDIQ RFQRD FVSRL WLTYR RDFPP LPGGC LTSDC GWGCM LRSGQ MMLAQ GLLLH FLPRD WTWAE GMGLG PPELS GSASP SRYHG PARWM PPRWA QGAPE LEQER RHRQI VSWFA DHPRA PFGLH |
| Synonyms: | APG4D, AUTL4, APG4-D, HsAPG4D |
| Calculated MW: | 53kDa |
| Observed MW: | Refer to figures |
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