Ataxin-3 (ATXN3) Monoclonal Antibody
- SKU:
- CAB22094
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Ataxin-3 (ATXN3) Monoclonal Antibody |
| Product Code: | CAB22094 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54882 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain, Rat brain |
| Cellular Location: | Nucleus matrix |
| Customer Validation: | WB(Homo sapiens) |
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-361 of human Ataxin-3 (ATXN3) (NP_004984.2). |
| Sequence: | KLIGE ELAQL KEQRV HKTDL ERVLE ANDGS GMLDE DEEDL QRALA LSRQE IDMED EEADL RRAIQ LSMQG SSRNI SQDMT QTSGT NLTSE ELRKR REAYF EKQQQ KQQQQ QQQQQ QGDLS GQSSH PCERP ATSSG ALGSD LGDAM SEEDM LQAAV TMSLE TVRND LKTEG KK |
| Synonyms: | AT3, JOS, MJD, ATX3, MJD1, SCA3 |
| Calculated MW: | 41kDa |
| Observed MW: | 42kDa |
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