ASC/TMS1 Monoclonal Antibody (CAB22046)
- SKU:
- CAB22046
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | ASC/TMS1 Monoclonal Antibody |
| Product Code: | CAB22046 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54741 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:2000-1:7000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | THP-1, U-937, Jurkat, Mouse thymus, Mouse spleen, Rat thymus |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus |
| Customer Validation: | WB(Mus musculus) |
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 4-110 of human ASC/TMS1 (NP_037390.2). |
| Sequence: | ARDAI LDALE NLTAE ELKKF KLKLL SVPLR EGYGR IPRGA LLSMD ALDLT DKLVS FYLET YGAEL TANVL RDMGL QEMAG QLQAA THQGS GAAPA GIQAP PQSAA KP |
| Synonyms: | ASC, TMS, TMS1, CARD5, TMS-1 |
| Calculated MW: | 22kDa |
| Observed MW: | 19kDa/22kDa |
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