Antibody Name:	ASB8 Antibody (PACO15782)
Antibody SKU:	PACO15782
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human ASB8

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: K562 cell, Primary antibody: PACO15782(ASB8 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15782(ASB8 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).

Background:

ASB-8 (ankyrin repeat and SOCS box-containing 8) is a 288 amino acid, member of the ASB family that contains one SOCS box domain and four ANK repeats. Localized to the cytoplasm, ASB-8 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins. The highest level of ASB-8 expression has been detected in skeletal muscle. ASB-8 is also expressed in heart, brain, placenta, liver, kidney and pancreas.

Synonyms:

ankyrin repeat and SOCS box containing 8

UniProt Protein Function:	ASB8: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.Chromosomal Location of Human Ortholog: 12q13.11Cellular Component: cytoplasmBiological Process: protein ubiquitination
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q9H765
NCBI GenInfo Identifier:	13129098
NCBI Gene ID:	140461
NCBI Accession:	NP_077000
UniProt Secondary Accession:	Q9H765,Q547Q2, A8K1P2
UniProt Related Accession:	Q9H765
Molecular Weight:	34.0 kDa (311aa) confirmed by MALDI-TOF
NCBI Full Name:	ankyrin repeat and SOCS box protein 8 isoform a
NCBI Synonym Full Names:	ankyrin repeat and SOCS box containing 8
NCBI Official Symbol:	ASB8
NCBI Official Synonym Symbols:	PP14212
NCBI Protein Information:	ankyrin repeat and SOCS box protein 8
UniProt Protein Name:	Ankyrin repeat and SOCS box protein 8
UniProt Synonym Protein Names:
Protein Family:	Ankyrin repeat and SOCS box protein
UniProt Gene Name:	ASB8
UniProt Entry Name:	ASB8_HUMAN