ASB10 Antibody (PACO39226)
- SKU:
- PACO39226
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ASB10 Antibody (PACO39226) |
| Antibody SKU: | PACO39226 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Ankyrin repeat and SOCS box protein 10 protein (1-300AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO39226 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO39226 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO39226 at dilution of 1:100. |
| Background: | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Synonyms: | Ankyrin repeat and SOCS box protein 10 (ASB-10), ASB10 |
| UniProt Protein Function: | ASB10: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 7q36.1Cellular Component: cytoplasm; nucleusDisease: Glaucoma 1, Open Angle, F |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q8WXI3 |
| NCBI GenInfo Identifier: | 126302522 |
| NCBI Gene ID: | 136371 |
| NCBI Accession: | Q8WXI3.2 |
| UniProt Secondary Accession: | Q8WXI3,Q6ZUL6, A0AVH0 |
| UniProt Related Accession: | Q8WXI3 |
| Molecular Weight: | 49,565 Da |
| NCBI Full Name: | Ankyrin repeat and SOCS box protein 10 |
| NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 10 |
| NCBI Official Symbol: | ASB10 |
| NCBI Official Synonym Symbols: | GLC1F |
| NCBI Protein Information: | ankyrin repeat and SOCS box protein 10 |
| UniProt Protein Name: | Ankyrin repeat and SOCS box protein 10 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ankyrin repeat and SOCS box protein |
| UniProt Gene Name: | ASB10 |
| UniProt Entry Name: | ASB10_HUMAN |
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