ARPP19 Antibody (PACO48562)
- SKU:
- PACO48562
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARPP19 Antibody (PACO48562) |
| Antibody SKU: | PACO48562 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human cAMP-regulated phosphoprotein 19 protein (2-105AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO48562 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO48562 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. |
| Synonyms: | cAMP-regulated phosphoprotein 19 (ARPP-19), ARPP19 |
| UniProt Protein Function: | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. |
| UniProt Protein Details: | |
| NCBI Summary: | The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011] |
| UniProt Code: | P56211 |
| NCBI GenInfo Identifier: | 5729732 |
| NCBI Gene ID: | 10776 |
| NCBI Accession: | NP_006619 |
| UniProt Secondary Accession: | P56211 |
| UniProt Related Accession: | P56211 |
| Molecular Weight: | |
| NCBI Full Name: | cAMP-regulated phosphoprotein 19 isoform 2 |
| NCBI Synonym Full Names: | cAMP regulated phosphoprotein 19 |
| NCBI Official Symbol: | ARPP19 |
| NCBI Official Synonym Symbols: | ENSAL; ARPP16; ARPP-16; ARPP-19 |
| NCBI Protein Information: | cAMP-regulated phosphoprotein 19 |
| UniProt Protein Name: | cAMP-regulated phosphoprotein 19 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | ARPP19 |
| UniProt Entry Name: |
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