ARPIN Antibody (PACO37454)
- SKU:
- PACO37454
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARPIN Antibody (PACO37454) |
| Antibody SKU: | PACO37454 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Arpin protein (1-226AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: ARPIN antibody at 0.5µg/ml + HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 25, 44 kDa. Observed band size: 25 kDa. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO37454 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO37454 at dilution of 1:100. |
| Background: | Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. |
| Synonyms: | Arpin (Arp2/3 inhibition protein), ARPIN, C15orf38 |
| UniProt Protein Function: | ARPIN: Belongs to the UPF0552 family.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q26.1Cellular Component: lamellipodiumMolecular Function: protein bindingBiological Process: directional locomotion; negative regulation of actin nucleation; negative regulation of cell migration |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7Z6K5 |
| NCBI GenInfo Identifier: | 538260582 |
| NCBI Gene ID: | 348110 |
| NCBI Accession: | NP_001269309.1 |
| UniProt Secondary Accession: | Q7Z6K5,E2QRD5 |
| UniProt Related Accession: | Q7Z6K5 |
| Molecular Weight: | 43,882 Da |
| NCBI Full Name: | arpin isoform 2 |
| NCBI Synonym Full Names: | actin-related protein 2/3 complex inhibitor |
| NCBI Official Symbol: | ARPIN |
| NCBI Official Synonym Symbols: | C15orf38 |
| NCBI Protein Information: | arpin |
| UniProt Protein Name: | Arpin |
| UniProt Synonym Protein Names: | Arp2/3 inhibition protein |
| Protein Family: | Arpin |
| UniProt Gene Name: | ARPIN |
| UniProt Entry Name: | ARPIN_HUMAN |
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