ARMET/ARP/MANF Monoclonal Antibody (CAB21080)
- SKU:
- CAB21080
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | ARMET/ARP/MANF Monoclonal Antibody |
| Product Code: | CAB21080 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52199 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HT-29, HepG2, BxPC-3, Mouse pancreas, Mouse testis, Mouse heart, Rat pancreas, Rat liver, Rat testis |
| Cellular Location: | Secreted |
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-182 of human MANF (NP_006001.5). |
| Sequence: | LRPGD CEVCI SYLGR FYQDL KDRDV TFSPA TIENE LIKFC REARG KENRL CYYIG ATDDA ATKII NEVSK PLAHH IPVEK ICEKL KKKDS QICEL KYDKQ IDLST VDLKK LRVKE LKKIL DDWGE TCKGC AEKSD YIRKI NELMP KYAPK AASAR TDL |
| Synonyms: | ARP, ARMET |
| Calculated MW: | 21kDa |
| Observed MW: | 16kDa |
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