ARIH2 Antibody (PACO19136)
- SKU:
- PACO19136
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARIH2 Antibody (PACO19136) |
| Antibody SKU: | PACO19136 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human ARIH2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Hela cells, Jurkat cells, 293T cells, K562 cells, mouse testis tissue, Primary antibody: PACO19136(ARIH2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
| Background: | TRIAD1, also known as ARIH2 (ariadne homolog 2) or ARI2, is a 493 amino acid, protein that contains one IBR-type zinc finger and two RING-type zinc fingers and belongs to the ariadne subfamily of RBR proteins. Localized to the nucleus, TRIAD1 interacts with UBE2L3 and is thought to act as an E3 ubiquitin-protein ligase, functioning to accept ubiquitin from E2 ubiquitin-conjugating enzymes and transfer the acquired ubiquitin residue to target substrates. TRIAD1 is subject to post-translational DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding TRIAD1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. |
| Synonyms: | ariadne homolog 2 (Drosophila) |
| UniProt Protein Function: | ARIH2: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys- 63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis. Belongs to the RBR family. Ariadne subfamily.Protein type: Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.-Chromosomal Location of Human Ortholog: 3p21Cellular Component: cytoplasm; nucleus; ubiquitin ligase complexMolecular Function: protein binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activityBiological Process: developmental cell growth; multicellular organismal development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015] |
| UniProt Code: | O95376 |
| NCBI GenInfo Identifier: | 18202259 |
| NCBI Gene ID: | 10425 |
| NCBI Accession: | O95376.1 |
| UniProt Secondary Accession: | O95376,Q9HBZ6, Q9UEM9 |
| UniProt Related Accession: | O95376 |
| Molecular Weight: | 57,819 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase ARIH2 |
| NCBI Synonym Full Names: | ariadne RBR E3 ubiquitin protein ligase 2 |
| NCBI Official Symbol: | ARIH2 |
| NCBI Official Synonym Symbols: | ARI2; TRIAD1 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase ARIH2 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase ARIH2 |
| UniProt Synonym Protein Names: | Triad1 protein |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | ARIH2 |
| UniProt Entry Name: | ARI2_HUMAN |
| Antibodies |
| ARIH2 Antibody (PACO07837) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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