ARHGEF6 Antibody (PACO61374)
- SKU:
- PACO61374
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARHGEF6 Antibody (PACO61374) |
| Antibody SKU: | PACO61374 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Rho guanine nucleotide exchange factor 6 protein (108-239AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61374 diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Synonyms: | Rho guanine nucleotide exchange factor 6, Alpha-Pix, COOL-2, PAK-interacting exchange factor alpha, Rac/Cdc42 guanine nucleotide exchange factor 6, ARHGEF6, COOL2, KIAA0006, PIXA |
| UniProt Protein Function: | ARHGEF6: Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/RhoChromosomal Location of Human Ortholog: Xq26.3Cellular Component: cytosol; intracellular; lamellipodiumMolecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transductionDisease: Mental Retardation, X-linked 46 |
| UniProt Protein Details: | |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15052 |
| NCBI GenInfo Identifier: | 17371603 |
| NCBI Gene ID: | 9459 |
| NCBI Accession: | Q15052.2 |
| UniProt Secondary Accession: | Q15052,Q15396, Q5JQ66, Q7Z3W1, Q86XH0, A6NMW9, A8K6S7 B1AL37 |
| UniProt Related Accession: | Q15052 |
| Molecular Weight: | 70,791 Da |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 6 |
| NCBI Synonym Full Names: | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| NCBI Official Symbol: | ARHGEF6 |
| NCBI Official Synonym Symbols: | PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 6 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 6 |
| UniProt Synonym Protein Names: | Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF6 |
| UniProt Entry Name: | ARHG6_HUMAN |
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