ARHGEF6 Antibody (PACO19131)
- SKU:
- PACO19131
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARHGEF6 Antibody (PACO19131) |
| Antibody SKU: | PACO19131 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human ARHGEF6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19131(ARHGEF6 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. |
| Synonyms: | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 |
| UniProt Protein Function: | ARHGEF6: Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/RhoChromosomal Location of Human Ortholog: Xq26.3Cellular Component: cytosol; intracellular; lamellipodiumMolecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transductionDisease: Mental Retardation, X-linked 46 |
| UniProt Protein Details: | |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15052 |
| NCBI GenInfo Identifier: | 17371603 |
| NCBI Gene ID: | 9459 |
| NCBI Accession: | Q15052.2 |
| UniProt Secondary Accession: | Q15052,Q15396, Q5JQ66, Q7Z3W1, Q86XH0, A6NMW9, A8K6S7 B1AL37 |
| UniProt Related Accession: | Q15052 |
| Molecular Weight: | 70,791 Da |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 6 |
| NCBI Synonym Full Names: | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| NCBI Official Symbol: | ARHGEF6 |
| NCBI Official Synonym Symbols: | PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 6 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 6 |
| UniProt Synonym Protein Names: | Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF6 |
| UniProt Entry Name: | ARHG6_HUMAN |
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