ARHGEF12 Antibody (PACO55278)
- SKU:
- PACO55278
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARHGEF12 Antibody (PACO55278) |
| Antibody SKU: | PACO55278 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Rho guanine nucleotide exchange factor 12 protein (1302-1501AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO55278 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO55278 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO55278 at dilution of 1:100. |
| Background: | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. |
| Synonyms: | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF), ARHGEF12, KIAA0382 LARG |
| UniProt Protein Function: | ARHGEF12: a widely-expressed guanine nucleotide exchange factor (GEF) for RhoA GTPase. May act as GTPase-activating protein (GAP) for G-alpha 12 and 13. The fusion protein MLL-ARHGEF12 appears to be a disease driver in acute myeloid leukemia. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; OncoproteinChromosomal Location of Human Ortholog: 11q23.3Cellular Component: cytoplasm; cytosolMolecular Function: G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9NZN5 |
| NCBI GenInfo Identifier: | 34395525 |
| NCBI Gene ID: | 23365 |
| NCBI Accession: | Q9NZN5.1 |
| UniProt Secondary Accession: | Q9NZN5,O15086, Q6P526 |
| UniProt Related Accession: | Q9NZN5 |
| Molecular Weight: | 173kDa |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 12 |
| NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor 12 |
| NCBI Official Symbol: | ARHGEF12 |
| NCBI Official Synonym Symbols: | LARG; PRO2792 |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 12 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 12 |
| UniProt Synonym Protein Names: | Leukemia-associated RhoGEF |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF12 |
| UniProt Entry Name: |
| Antibodies |
| ARHGEF12 Antibody (PACO02767) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost