Name: ARHGEF12 Antibody (PACO22572)
SKU: PACO22572
Availability: OutOfStock

Antibody Name:	ARHGEF12 Antibody (PACO22572)
Antibody SKU:	PACO22572
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human ARHGEF12.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from RAW264.7 cells, using ARHGEF12 antibody.

Background:	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Synonyms:	ARHGC; ARHGEF12; Leukemia-associated RhoGEF; RHO guanine nucleotide exchange factor (GEF) 12 (LARG); Rho guanine nucleotide exchange factor 12

UniProt Protein Function:	ARHGEF12: a widely-expressed guanine nucleotide exchange factor (GEF) for RhoA GTPase. May act as GTPase-activating protein (GAP) for G-alpha 12 and 13. The fusion protein MLL-ARHGEF12 appears to be a disease driver in acute myeloid leukemia. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; OncoproteinChromosomal Location of Human Ortholog: 11q23.3Cellular Component: cytoplasm; cytosolMolecular Function: G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:	Q9NZN5
NCBI GenInfo Identifier:	34395525
NCBI Gene ID:	23365
NCBI Accession:	Q9NZN5.1
UniProt Secondary Accession:	Q9NZN5,O15086, Q6P526
UniProt Related Accession:	Q9NZN5
Molecular Weight:	173kDa
NCBI Full Name:	Rho guanine nucleotide exchange factor 12
NCBI Synonym Full Names:	Rho guanine nucleotide exchange factor 12
NCBI Official Symbol:	ARHGEF12
NCBI Official Synonym Symbols:	LARG; PRO2792
NCBI Protein Information:	rho guanine nucleotide exchange factor 12
UniProt Protein Name:	Rho guanine nucleotide exchange factor 12
UniProt Synonym Protein Names:	Leukemia-associated RhoGEF
Protein Family:	Rho guanine nucleotide exchange factor
UniProt Gene Name:	ARHGEF12
UniProt Entry Name: