Antibody Name:	ARHGEF12 Antibody (PACO19922)
Antibody SKU:	PACO19922
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human ARHGEF12

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19922(ARHGEF12 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO19922(ARHGEF12 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms:

Rho guanine nucleotide exchange factor (GEF) 12

UniProt Protein Function:	ARHGEF12: a widely-expressed guanine nucleotide exchange factor (GEF) for RhoA GTPase. May act as GTPase-activating protein (GAP) for G-alpha 12 and 13. The fusion protein MLL-ARHGEF12 appears to be a disease driver in acute myeloid leukemia. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; OncoproteinChromosomal Location of Human Ortholog: 11q23.3Cellular Component: cytoplasm; cytosolMolecular Function: G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:	Q9NZN5
NCBI GenInfo Identifier:	34395525
NCBI Gene ID:	23365
NCBI Accession:	Q9NZN5.1
UniProt Secondary Accession:	Q9NZN5,O15086, Q6P526
UniProt Related Accession:	Q9NZN5
Molecular Weight:	173kDa
NCBI Full Name:	Rho guanine nucleotide exchange factor 12
NCBI Synonym Full Names:	Rho guanine nucleotide exchange factor 12
NCBI Official Symbol:	ARHGEF12
NCBI Official Synonym Symbols:	LARG; PRO2792
NCBI Protein Information:	rho guanine nucleotide exchange factor 12
UniProt Protein Name:	Rho guanine nucleotide exchange factor 12
UniProt Synonym Protein Names:	Leukemia-associated RhoGEF
Protein Family:	Rho guanine nucleotide exchange factor
UniProt Gene Name:	ARHGEF12
UniProt Entry Name: