Description
Antibody Name: | ARHGEF12 Antibody |
Antibody SKU: | PACO02767 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human LARG. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ARHGEF12; KIAA0382; LARG; Rho guanine nucleotide exchange factor 12; Leukemia-associated RhoGEF |
UniProt Protein Function: | ARHGEF12: a widely-expressed guanine nucleotide exchange factor (GEF) for RhoA GTPase. May act as GTPase-activating protein (GAP) for G-alpha 12 and 13. The fusion protein MLL-ARHGEF12 appears to be a disease driver in acute myeloid leukemia. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; OncoproteinChromosomal Location of Human Ortholog: 11q23.3Cellular Component: cytoplasm; cytosolMolecular Function: G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction |
UniProt Protein Details: | |
NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
UniProt Code: | Q9NZN5 |
NCBI GenInfo Identifier: | 34395525 |
NCBI Gene ID: | 23365 |
NCBI Accession: | Q9NZN5.1 |
UniProt Secondary Accession: | Q9NZN5,O15086, Q6P526 |
UniProt Related Accession: | Q9NZN5 |
Molecular Weight: | 173kDa |
NCBI Full Name: | Rho guanine nucleotide exchange factor 12 |
NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor 12 |
NCBI Official Symbol: | ARHGEF12 |
NCBI Official Synonym Symbols: | LARG; PRO2792 |
NCBI Protein Information: | rho guanine nucleotide exchange factor 12 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 12 |
UniProt Synonym Protein Names: | Leukemia-associated RhoGEF |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF12 |
UniProt Entry Name: |