Description
Antibody Name: | ARHGEF10 Antibody (PACO15513) |
Antibody SKU: | PACO15513 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ARHGEF10 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15513(ARHGEF10 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15513(ARHGEF10 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. ARHGEF10 (rho guanine nucleotide exchange factor 10), also known as GEF10 or KIAA0294, is a 1,369 amino acid, protein that contains one DBL-homology domain and is thought to play a role in myelination of peripheral nerves, specifically during development. ARHGEF10 is expressed as four alternatively spliced isoforms that are present at low levels in ovary, lung, testis and kidney, with considerably higher expression in the central and peripheral nervous systems. |
Synonyms: | Rho guanine nucleotide exchange factor (GEF) 10 |
UniProt Protein Function: | ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rac/Rho; GEFsChromosomal Location of Human Ortholog: 8p23Cellular Component: centrosome; cytosolMolecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; kinesin bindingBiological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous systemDisease: Slowed Nerve Conduction Velocity, Autosomal Dominant |
UniProt Protein Details: | |
NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15013 |
NCBI GenInfo Identifier: | 62548864 |
NCBI Gene ID: | 9639 |
NCBI Accession: | NP_055444.2 |
UniProt Secondary Accession: | O15013,O14665, Q2KHR8, Q68D55, Q8IWD9, Q8IY77 |
UniProt Related Accession: | O15013 |
Molecular Weight: | 151,612 Da |
NCBI Full Name: | rho guanine nucleotide exchange factor 10 |
NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor (GEF) 10 |
NCBI Official Symbol: | ARHGEF10 |
NCBI Official Synonym Symbols: | GEF10 |
NCBI Protein Information: | rho guanine nucleotide exchange factor 10 |
UniProt Protein Name: | Rho guanine nucleotide exchange factor 10 |
UniProt Synonym Protein Names: | |
Protein Family: | Rho guanine nucleotide exchange factor |
UniProt Gene Name: | ARHGEF10 |
UniProt Entry Name: | ARHGA_HUMAN |