ARHGEF10 Antibody (PACO00420)
- SKU:
- PACO00420
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- NHP - Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARHGEF10 Antibody |
| Antibody SKU: | PACO00420 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Monkey |
| Immunogen: | synthesized peptide derived from the Internal region of human ARHGEF10. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ARHGEF10; KIAA0294; Rho guanine nucleotide exchange factor 10 |
| UniProt Protein Function: | ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rac/Rho; GEFsChromosomal Location of Human Ortholog: 8p23Cellular Component: centrosome; cytosolMolecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; kinesin bindingBiological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous systemDisease: Slowed Nerve Conduction Velocity, Autosomal Dominant |
| UniProt Protein Details: | |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15013 |
| NCBI GenInfo Identifier: | 62548864 |
| NCBI Gene ID: | 9639 |
| NCBI Accession: | NP_055444.2 |
| UniProt Secondary Accession: | O15013,O14665, Q2KHR8, Q68D55, Q8IWD9, Q8IY77 |
| UniProt Related Accession: | O15013 |
| Molecular Weight: | 151,612 Da |
| NCBI Full Name: | rho guanine nucleotide exchange factor 10 |
| NCBI Synonym Full Names: | Rho guanine nucleotide exchange factor (GEF) 10 |
| NCBI Official Symbol: | ARHGEF10 |
| NCBI Official Synonym Symbols: | GEF10 |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 10 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 10 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF10 |
| UniProt Entry Name: | ARHGA_HUMAN |
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