ARHGDIG Antibody (PACO47014)
- SKU:
- PACO47014
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARHGDIG Antibody (PACO47014) |
| Antibody SKU: | PACO47014 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Rho GDP-dissociation inhibitor 3 protein (1-225AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: ARHGDIG antibody at 2 µg/ml. Lane 1: Mouse brain tissue. Lane 2: Mouse lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 25 kDa. Observed band size: 25, 50 kDa.. |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO47014 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO47014 at dilution of 1:100. |
| Background: | Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. |
| Synonyms: | Rho GDP-dissociation inhibitor 3 (Rho GDI 3) (Rho-GDI gamma), ARHGDIG |
| UniProt Protein Function: | RhoGDI gamma: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. Belongs to the Rho GDI family.Protein type: Inhibitor; Motility/polarity/chemotaxis; G protein regulator, misc.; Cell adhesionChromosomal Location of Human Ortholog: 16p13.3Cellular Component: membrane; cytoplasmic membrane-bound vesicle; cytosolMolecular Function: Rho GDP-dissociation inhibitor activity; GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; regulation of protein localization; small GTPase mediated signal transduction; negative regulation of cell adhesion; Rho protein signal transduction; positive regulation of GTPase activity |
| UniProt Protein Details: | |
| NCBI Summary: | The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q99819 |
| NCBI GenInfo Identifier: | 28839701 |
| NCBI Gene ID: | 398 |
| NCBI Accession: | AAH47699.1 |
| UniProt Secondary Accession: | Q99819,Q4TT69, Q96S29 |
| UniProt Related Accession: | Q99819 |
| Molecular Weight: | |
| NCBI Full Name: | Rho GDP dissociation inhibitor (GDI) gamma |
| NCBI Synonym Full Names: | Rho GDP dissociation inhibitor (GDI) gamma |
| NCBI Official Symbol: | ARHGDIG |
| NCBI Official Synonym Symbols: | RHOGDI-3 |
| NCBI Protein Information: | rho GDP-dissociation inhibitor 3; rho GDI 3; RhoGDI gamma; rho-GDI gamma |
| UniProt Protein Name: | Rho GDP-dissociation inhibitor 3 |
| UniProt Synonym Protein Names: | Rho-GDI gamma |
| Protein Family: | Rho GDP-dissociation inhibitor |
| UniProt Gene Name: | ARHGDIG |
| UniProt Entry Name: | GDIR3_HUMAN |
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