ARHGAP9 Antibody (PACO22569)
- SKU:
- PACO22569
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARHGAP9 Antibody (PACO22569) |
| Antibody SKU: | PACO22569 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human RHG9. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from LOVO cells, using RHG9 antibody. |
| Background: | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. |
| Synonyms: | RGL1; RHG09; rho GTPase activating 9; |
| UniProt Protein Function: | ARHGAP9: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; Cell adhesion; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 12q13.3Cellular Component: cytosolMolecular Function: phosphatidylinositol-3,4,5-triphosphate binding; GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BRR9 |
| NCBI GenInfo Identifier: | 122939149 |
| NCBI Gene ID: | 64333 |
| NCBI Accession: | NP_001073625.1 |
| UniProt Secondary Accession: | Q9BRR9,Q8NAF3, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74, B4DVI3 E9PDX9 |
| UniProt Related Accession: | Q9BRR9 |
| Molecular Weight: | 83,260 Da |
| NCBI Full Name: | rho GTPase-activating protein 9 isoform 3 |
| NCBI Synonym Full Names: | Rho GTPase activating protein 9 |
| NCBI Official Symbol: | ARHGAP9 |
| NCBI Official Synonym Symbols: | 10C; RGL1 |
| NCBI Protein Information: | rho GTPase-activating protein 9; rho-type GTPase-activating protein 9 |
| UniProt Protein Name: | Rho GTPase-activating protein 9 |
| UniProt Synonym Protein Names: | Rho-type GTPase-activating protein 9 |
| Protein Family: | |
| UniProt Gene Name: | ARHGAP9 |
| UniProt Entry Name: | RHG09_HUMAN |
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