Description
Antibody Name: | ARHGAP29 Antibody (PACO36082) |
Antibody SKU: | PACO36082 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Rho GTPase-activating protein 29 protein (161-392AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. |
Synonyms: | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29), ARHGAP29, PARG1 |
UniProt Protein Function: | ARHGAP29: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 1p22.1Cellular Component: cytoplasm; cytosolMolecular Function: GTPase activator activity; PDZ domain bindingBiological Process: regulation of small GTPase mediated signal transduction; Rho protein signal transduction |
UniProt Protein Details: | |
NCBI Summary: | Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016] |
UniProt Code: | Q52LW3 |
NCBI GenInfo Identifier: | 18490366 |
NCBI Gene ID: | 9411 |
NCBI Accession: | BC022483 |
UniProt Secondary Accession: | Q52LW3,O15463, Q59H86, Q5VYZ0, Q6NVX2, Q8TBI6 |
UniProt Related Accession: | Q52LW3 |
Molecular Weight: | 45,194 Da |
NCBI Full Name: | Homo sapiens Rho GTPase activating protein 29, mRNA |
NCBI Synonym Full Names: | Rho GTPase activating protein 29 |
NCBI Official Symbol: | ARHGAP29 |
NCBI Official Synonym Symbols: | PARG1 |
NCBI Protein Information: | rho GTPase-activating protein 29 |
UniProt Protein Name: | Rho GTPase-activating protein 29 |
UniProt Synonym Protein Names: | PTPL1-associated RhoGAP protein 1; Rho-type GTPase-activating protein 29 |
Protein Family: | Rho GTPase-activating protein |
UniProt Gene Name: | ARHGAP29 |
UniProt Entry Name: | RHG29_HUMAN |