ARAP3 Antibody (PACO52542)
- SKU:
- PACO52542
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ARAP3 Antibody (PACO52542) |
| Antibody SKU: | PACO52542 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 protein (163-320AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO52542 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO52542 at dilution of 1:100. |
| Background: | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. |
| Synonyms: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3), ARAP3, CENTD3 |
| UniProt Protein Function: | ARAP3: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.Protein type: GAPs, ARF; Motility/polarity/chemotaxis; GAPsChromosomal Location of Human Ortholog: 5q31.3Cellular Component: ruffle; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; cytosolMolecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding; zinc ion binding; phosphatidylinositol-3,4-bisphosphate bindingBiological Process: vesicle-mediated transport; negative regulation of Rac protein signal transduction; regulation of cell shape; regulation of small GTPase mediated signal transduction; negative regulation of Rho protein signal transduction; small GTPase mediated signal transduction; cytoskeleton organization and biogenesis; negative regulation of cell migration |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2008] |
| UniProt Code: | Q8WWN8 |
| NCBI GenInfo Identifier: | 33988551 |
| NCBI Gene ID: | 64411 |
| NCBI Accession: | BC009968 |
| UniProt Secondary Accession: | Q8WWN8,B4DIT1, D3DQE3 |
| UniProt Related Accession: | Q8WWN8 |
| Molecular Weight: | 131,986 Da |
| NCBI Full Name: | Homo sapiens ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3, mRNA |
| NCBI Synonym Full Names: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| NCBI Official Symbol: | ARAP3 |
| NCBI Official Synonym Symbols: | DRAG1; CENTD3 |
| NCBI Protein Information: | arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3; Arf and Rho GAP adapter protein 3; PtdIns(3,4,5)P3-binding protein; centaurin, delta 3; centaurin-delta-3; cnt-d3; phosphoinositide binding protein |
| UniProt Protein Name: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 |
| UniProt Synonym Protein Names: | Centaurin-delta-3; Cnt-d3 |
| Protein Family: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein |
| UniProt Gene Name: | ARAP3 |
| UniProt Entry Name: | ARAP3_HUMAN |
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