Natural Proteins Recombinant Proteins

Aprotinin Protein Recombinant Protein (RPPB2898)

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SKU:
RPPB2898
Product Type:
Recombinant Protein
Uniprot:
P00974
Research Area:
Natural Proteins

Description

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Product Name:Aprotinin Protein Recombinant Protein
Product Code:RPPB2898
Size:250mg
Target:Aprotinin Protein
Synonyms:Pancreatic trypsin inhibitor, Basic protease inhibitor, BPI, BPTI, Aprotinin, AP.
Source:Bovine Lung
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein (1mg/ml) was lyophilized with no additives.
Solubility:It is recommended to reconstitute the lyophilized Aprotinin in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Aprotinin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Aprotinin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
UniProt Code:P00974

Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. Aprotinin is present in blood and in most tissues, with a high concentration in lung. Aprotinin inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins (e.g., CD11b).

Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids {C284H432N84O79S7} arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512.

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