Name: APLN Antibody (PACO20970)
SKU: PACO20970
Availability: OutOfStock

Antibody Name:	APLN Antibody (PACO20970)
Antibody SKU:	PACO20970
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human APLN

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20970(APLN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.

Synonyms:

apelin

UniProt Protein Function:	apelin: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Belongs to the apelin family.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xq25 Cellular Component: extracellular space; extracellular region Molecular Function:G-protein-coupled receptor binding; hormone activity; apelin receptor binding; receptor binding Biological Process: lactation; immune response; signal transduction
NCBI Summary:	This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]
UniProt Code:	Q9ULZ1
NCBI GenInfo Identifier:	20137569
NCBI Gene ID:	8862
NCBI Accession:	Q9ULZ1.1
UniProt Secondary Accession:	Q9ULZ1,Q4VY08, Q8WU89,
UniProt Related Accession:	Q9ULZ1
Molecular Weight:	8,569 Da
NCBI Full Name:	Apelin
NCBI Synonym Full Names:	apelin
NCBI Official Symbol:	APLN
NCBI Official Synonym Symbols:	APEL; XNPEP2
NCBI Protein Information:	apelin; AGTRL1 ligand; APJ endogenous ligand
UniProt Protein Name:	Apelin
UniProt Synonym Protein Names:	APJ endogenous ligand
UniProt Gene Name:	APLN
UniProt Entry Name:	APEL_HUMAN

Antibodies	ELISA Kits
Anti-APLN Antibody (CAB18168)	Human Apelin ELISA Kit
APLN Antibody (PACO01877)	Human APLN (Apelin) ELISA Kit (HUES01662)
APLN Antibody (PACO07784)	Human Apelin (APLN) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)