APC2 Antibody (PACO62235)
- SKU:
- PACO62235
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | APC2 Antibody (PACO62235) |
| Antibody SKU: | PACO62235 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Adenomatous polyposis coli protein 2 protein (2011-2221AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of A549 cells with PACO62235 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1. |
| Synonyms: | Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like), APC2, APCL |
| UniProt Protein Function: | APCL: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. Belongs to the adenomatous polyposis coli (APC) family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, peripheralChromosomal Location of Human Ortholog: 19p13.3Cellular Component: actin filament; beta-catenin destruction complex; catenin complex; cytoplasm; cytoplasmic microtubule; Golgi apparatus; microtubule cytoskeleton; perinuclear region of cytoplasmMolecular Function: beta-catenin binding; gamma-catenin binding; protein bindingBiological Process: cell fate specification; cell migration; cell proliferation; negative regulation of microtubule depolymerization; pattern specification process; positive regulation of protein catabolic process; regulation of cell differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O95996 |
| NCBI GenInfo Identifier: | 74722250 |
| NCBI Gene ID: | 10297 |
| NCBI Accession: | O95996.1 |
| UniProt Secondary Accession: | O95996,Q05BW4, Q9UBZ1, Q9UEM8, Q9UQJ8, Q9UQJ9, Q9Y632 |
| UniProt Related Accession: | O95996 |
| Molecular Weight: | 243,821 Da |
| NCBI Full Name: | Adenomatous polyposis coli protein 2 |
| NCBI Synonym Full Names: | APC2, WNT signaling pathway regulator |
| NCBI Official Symbol: | APC2 |
| NCBI Official Synonym Symbols: | APCL |
| NCBI Protein Information: | adenomatous polyposis coli protein 2 |
| UniProt Protein Name: | Adenomatous polyposis coli protein 2 |
| UniProt Synonym Protein Names: | Adenomatous polyposis coli protein-like; APC-like |
| Protein Family: | Acetophenone carboxylase |
| UniProt Gene Name: | APC2 |
| UniProt Entry Name: | APC2_HUMAN |
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