APC Monoclonal Antibody
- SKU:
- CAB22073
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | APC Monoclonal Antibody |
| Product Code: | CAB22073 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53932 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:100-1:500, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, HeLa |
| Cellular Location: | Cell junction, Cell membrane, Cell projection, Cytoplasm, adherens junction, cytoskeleton, lamellipodium, ruffle membrane |
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2600-2760 of human APC (NP_000029.2). |
| Sequence: | QSKEN QVSAK GTWRK IKENE FSPTN STSQT VSSGA TNGAE SKTLI YQMAP AVSKT EDVWV RIEDC PINNP RSGRS PTGNT PPVID SVSEK ANPNI KDSKD NQAKQ NVGNG SVPMR TVGLE NRLNS FIQVD APDQK GTEIK PGQNN PVPVS ETNES SIVER T |
| Synonyms: | GS, DP2, DP3, BTPS2, DESMD, DP2.5, PPP1R46 |
| Calculated MW: | 312kDa |
| Observed MW: | 160kDa |
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