APC Anti-Rat CD44H Antibody [OX-49] (AGEL2433)

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SKU:
AGEL2433
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Rat
Host Species:
Mouse
Isotype:
Mouse IgG2a, κ
Clone:
OX-49
Conjugation:
APC

Description

Product Name:APC Anti-Rat CD44H Antibody [OX-49] (AGEL2433)
Product Code:AGEL2433
Clone No:OX-49
Synonyms:Pgp-1, H-CAM, CD44s,CD44H
Reactivity:Rat
Host Species:Mouse
Applications:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:APC Mouse IgG2b, κ Isotype Control [MPC-11] (AGEL2597)
Conjugation:APC
Form:Liquid
Fluorescent Label:APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Swissprot:P26051
Stability & Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

CD44 is an 80-95 kD cell surface glycoprotein. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It is up-regulated when T cells and B cells are activated. It was reported that CD44 is a valuable marker for memory T cells. CD44 is an adhesion molecule involved in leukocyte adhesion and homing to lymphoid organs. The OX-49 antibody reacts with CD44H (known as CD44s) expressed on most leukocytes, except for a subset of B lymphocytes. The epitope recognized by OX-49 antibody has been mapped to a region on both the standard, CD44s, and the splice variant, CD44v, isoforms of CD44. However it was reported that OX-49 antibody cannot detect the CD44V isoform, possibly due to conformational changes in the epitope.

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