Antibody Name:	ANXA8 Antibody (PACO14043)
Antibody SKU:	PACO14043
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human ANXA8

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14043(ANXA8 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO14043(ANXA8 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO14043(ANXA8 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.

Synonyms:

annexin A8

UniProt Protein Function:	ANXA8: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Belongs to the annexin family.Chromosomal Location of Human Ortholog: 10q11.22Cellular Component: late endosome membrane; plasma membrane; cytosolMolecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; calcium-dependent phospholipid binding; calcium ion binding; phosphatidylinositol-3,4-bisphosphate bindingBiological Process: endosome organization and biogenesis; blood coagulation; endosome transport
UniProt Protein Details:
NCBI Summary:	This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
UniProt Code:	P13928
NCBI GenInfo Identifier:	49257004
NCBI Gene ID:	653145
NCBI Accession:	AAH73755.1
UniProt Secondary Accession:	P13928,Q5VTM4, Q6GMY3, Q9BT34, A6NLM1
UniProt Related Accession:	P13928
Molecular Weight:	36,881 Da
NCBI Full Name:	Annexin A8
NCBI Synonym Full Names:	annexin A8
NCBI Official Symbol:	ANXA8
NCBI Official Synonym Symbols:	ANX8
NCBI Protein Information:	annexin A8; VAC-beta; annexin-8; annexin VIII; vascular anticoagulant-beta
UniProt Protein Name:	Annexin A8
UniProt Synonym Protein Names:	Annexin VIII; Annexin-8; Vascular anticoagulant-beta; VAC-beta
Protein Family:	Annexin
UniProt Gene Name:	ANXA8
UniProt Entry Name:	ANXA8_HUMAN