ANXA2R Antibody (PACO19333)
- SKU:
- PACO19333
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ANXA2R Antibody (PACO19333) |
| Antibody SKU: | PACO19333 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human ANXA2R |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19333(ANXA2R Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO19333(ANXA2R Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | ANXA2R (annexin-2 receptor), also known as AX2R or C5orf39, is a 193 amino acid, protein that is widely expressed and may act as an annexin II receptor on marrow stromal cells to induce osteoclast formation. In addition, ANXA2R is highly expressed in lymphocytes and is also found in resting CD4+ and CD8+ T cells. The gene encoding ANXA2R maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. |
| Synonyms: | annexin A2 receptor |
| UniProt Protein Function: | Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factor; Oncoprotein; DNA-bindingChromosomal Location of Human Ortholog: 6q22-q23Cellular Component: nuclear matrix; cytosolMolecular Function: protein binding; chromatin bindingBiological Process: positive regulation of histone H3-K9 methylation; thymus development; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; homeostasis of number of cells; positive regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; chromatin remodeling; positive regulation of T-helper cell differentiation; regulation of transcription, DNA-dependent; calcium ion transport; B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; blood coagulation; embryonic gut development; G1/S transition of mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q3ZCQ2 |
| NCBI GenInfo Identifier: | 62122950 |
| NCBI Gene ID: | 389289 |
| NCBI Accession: | NP_001014301 |
| UniProt Secondary Accession: | Q3ZCQ2,Q8NHX5 |
| UniProt Related Accession: | Q3ZCQ2 |
| Molecular Weight: | |
| NCBI Full Name: | annexin-2 receptor |
| NCBI Synonym Full Names: | annexin A2 receptor |
| NCBI Official Symbol: | ANXA2R |
| NCBI Official Synonym Symbols: | AX2R; AXIIR; C5orf39 |
| NCBI Protein Information: | annexin-2 receptor; annexin II receptor |
| UniProt Protein Name: | Transcriptional activator Myb |
| UniProt Synonym Protein Names: | Proto-oncogene c-Myb |
| Protein Family: | Myb protein |
| UniProt Gene Name: | MYB |
| UniProt Entry Name: | MYB_HUMAN |
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