Anti-Zyxin Antibody (CAB2298)

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SKU:
CAB2298
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ESP-2
Synonyms:
HED-2
Research Area:
Cell Biology

Description

Product Name:Zyxin Rabbit mAb
Product Code:CAB2298
Size:20uL, 50uL, 100uL
Synonyms:ESP-2, HED-2
Applications:WB, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Zyxin
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:MCF7, Mouse lung
Immunogen:A synthesized peptide derived from human Zyxin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7791
Uniprot:Q15942
Cellular Location:Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion
Calculated MW:78kDa
Observed MW:78kDa
UniProt Protein Function:Zyxin: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Belongs to the zyxin/ajuba family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: focal adhesion; cell-cell adherens junction; integral to plasma membrane; cytoplasm; stress fiber; plasma membrane; nucleus

Molecular Function:protein binding; zinc ion binding

Biological Process: integrin-mediated signaling pathway; cell-cell signaling; viral reproduction; transforming growth factor beta receptor signaling pathway; cell-matrix adhesion; regulation of inflammatory response; stress fiber formation; signal transduction; cell adhesion

NCBI Summary:Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
UniProt Code:Q15942
NCBI GenInfo Identifier:2497677
NCBI Gene ID:7791
NCBI Accession:Q15942.1
UniProt Secondary Accession:Q15942,Q6I9S4, A4D2G6, B4DQX7,
UniProt Related Accession:Q15942
Molecular Weight:572
NCBI Full Name:Zyxin
NCBI Synonym Full Names:zyxin
NCBI Official Symbol:ZYX  
NCBI Official Synonym Symbols:ESP-2; HED-2  
NCBI Protein Information:zyxin; zyxin-2
UniProt Protein Name:Zyxin
UniProt Synonym Protein Names:Zyxin-2
Protein Family:Zyxin
UniProt Gene Name:ZYX  
UniProt Entry Name:ZYX_HUMAN
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