Signal Transduction Antibodies 2
Anti-ZNRF3 Antibody (CAB16026)
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- SKU:
- CAB16026
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ZNRF3 Antibody |
| Antibody SKU: | CAB16026 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ZNRF3 (NP_115549.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, HepG2, Mouse testis |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ZNRF3 (NP_115549.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MHPL GLCN NNDE EDLY EYGW VGVV KLEQ PELD PKPC LTVL GKAK RAVQ RGAT AVIF DVSE NPEA IDQL NQGS EDPL KRPV VYVK GADA IKLM NIVN KQKV |
| Gene ID: | 84133 |
| Uniprot: | Q9ULT6 |
| Cellular Location: | |
| Calculated MW: | 100kDa |
| Observed MW: | 120kDa |
| Synonyms: | ZNRF3, BK747E2.3, RNF203 |
| Background: |
| UniProt Protein Function: | ZNRF3: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Belongs to the ZNRF3 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ubiquitin conjugating system; Membrane protein, integral; Ubiquitin ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 22q12.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:frizzled binding; ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding Biological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway |
| UniProt Code: | Q9ULT6 |
| NCBI GenInfo Identifier: | 332801080 |
| NCBI Gene ID: | 84133 |
| NCBI Accession: | NP_001193927.1 |
| UniProt Secondary Accession: | Q9ULT6,Q6ICH1, Q6NTF8, Q8WU18, B3KU18, |
| UniProt Related Accession: | Q9ULT6 |
| Molecular Weight: | 34.2 kDa |
| NCBI Full Name: | E3 ubiquitin-protein ligase ZNRF3 isoform 1 |
| NCBI Synonym Full Names: | zinc and ring finger 3 |
| NCBI Official Symbol: | ZNRF3 |
| NCBI Official Synonym Symbols: | RNF203; BK747E2.3 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase ZNRF3 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase ZNRF3 |
| UniProt Synonym Protein Names: | RING finger protein 203; Zinc/RING finger protein 3 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | ZNRF3 |
| UniProt Entry Name: | ZNRF3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ZNRF3 antibody (CAB16026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver using ZNRF3 antibody (CAB16026) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using ZNRF3 antibody (CAB16026) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat lung using ZNRF3 antibody (CAB16026) at dilution of 1:100 (40x lens). |
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