Epigenetics & Nuclear Signaling Antibodies 1

Anti-ZNRD1 Antibody (CAB13088)

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SKU:
CAB13088
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ZNRD1 Antibody
Antibody SKU:CAB13088
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human ZNRD1 (NP_055411.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:K-562, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human ZNRD1 (NP_055411.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSVM DLAN TCSS FQSD LDFC SDCG SVLP LPGA QDTV TCIR CGFN INVR DFEG KVVK TSVV FHQL GTAM PMSV EEGP ECQG PVVD RRCP RCGH EGMA YHTR QMRS ADEG QTVF YTCT NCKF QEKE DS
Gene ID:30834
Uniprot:Q9P1U0
Cellular Location:Nucleus, nucleolus
Calculated MW:13kDa
Observed MW:14kDa
Synonyms:ZNRD1, HTEX-6, HTEX6, Rpa12, TCTEX6, TEX6, ZR14, hZR14, tctex-6
Background:This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ZNRD1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
UniProt Protein Details:

Protein type:Transcription initiation complex; Transferase; Nucleolus

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: DNA-directed RNA polymerase I complex; nucleoplasm

Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter

NCBI Summary:This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q9P1U0
NCBI GenInfo Identifier:71649339
NCBI Gene ID:30834
NCBI Accession:Q9P1U0.1
UniProt Secondary Accession:Q9P1U0,Q1RMP0, Q5TM50, Q791N7, Q1XHV8, Q6MFY5,
UniProt Related Accession:Q9P1U0
Molecular Weight:13,904 Da
NCBI Full Name:DNA-directed RNA polymerase I subunit RPA12
NCBI Synonym Full Names:zinc ribbon domain containing 1
NCBI Official Symbol:ZNRD1  
NCBI Official Synonym Symbols:TEX6; ZR14; HTEX6; Rpa12; hZR14; HTEX-6; TCTEX6; tctex-6  
NCBI Protein Information:DNA-directed RNA polymerase I subunit RPA12
UniProt Protein Name:DNA-directed RNA polymerase I subunit RPA12
UniProt Synonym Protein Names:Zinc ribbon domain-containing protein 1
UniProt Gene Name:ZNRD1  
UniProt Entry Name:RPA12_HUMAN
Anti-ZNRD1 Antibody (CAB13088)Western blot analysis of extracts of various cell lines, using ZNRD1 antibody (CAB13088) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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