Epigenetics & Nuclear Signaling Antibodies 3
Anti-ZNF703 Antibody (CAB14325)
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- SKU:
- CAB14325
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ZNF703 Antibody |
| Antibody SKU: | CAB14325 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-290 of human ZNF703 (NP_079345.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-290 of human ZNF703 (NP_079345.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GSGG GDSR KDSG SSSV SSTS SSSS SSPG DKAG FRVP SAAC PPFP PHGA PVSA SSSS SSPG GSRG GSPH HSDC KNGG GVGG GELD KKDQ EPKP SPEP AAVS RGGG GEPG AHGG AESG ASGR KSEP PSAL VGA |
| Gene ID: | 80139 |
| Uniprot: | Q9H7S9 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 58kDa |
| Observed MW: | 58kDa |
| Synonyms: | ZNF703, NLZ1, ZEPPO1, ZNF503L, ZPO1 |
| Background: |
| UniProt Protein Function: | ZNF703: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation. Belongs to the Elbow/Noc family. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 8p11.23 Cellular Component: protein complex; nuclear matrix; cytoplasm; nucleus Molecular Function:protein binding; nucleic acid binding; metal ion binding Biological Process: regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of cell cycle; negative regulation of homotypic cell-cell adhesion; positive regulation of cell proliferation; positive regulation of mammary gland epithelial cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of cell migration |
| UniProt Code: | Q9H7S9 |
| NCBI GenInfo Identifier: | 74761508 |
| NCBI Gene ID: | 80139 |
| NCBI Accession: | Q9H7S9.1 |
| UniProt Secondary Accession: | Q9H7S9,Q5XG76, |
| UniProt Related Accession: | Q9H7S9 |
| Molecular Weight: | 590 |
| NCBI Full Name: | Zinc finger protein 703 |
| NCBI Synonym Full Names: | zinc finger protein 703 |
| NCBI Official Symbol: | ZNF703 |
| NCBI Official Synonym Symbols: | NLZ1; ZPO1; ZEPPO1; ZNF503L |
| NCBI Protein Information: | zinc finger protein 703; zinc finger elbow-related proline domain protein 1 |
| UniProt Protein Name: | Zinc finger protein 703 |
| UniProt Synonym Protein Names: | Zinc finger elbow-related proline domain protein 1 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZNF703 |
| UniProt Entry Name: | ZN703_HUMAN |
 | Western blot analysis of extracts of MCF7 cells, using ZNF703 antibody (CAB14325) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat pancreas using ZNF703 antibody (CAB14325) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using ZNF703 antibody (CAB14325) at dilution of 1:100 (40x lens). |
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