Epigenetics & Nuclear Signaling Antibodies 4
Anti-ZNF408 Antibody (CAB8512)
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- SKU:
- CAB8512
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ZNF408 Antibody |
| Antibody SKU: | CAB8512 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 471-720 of human ZNF408 (NP_079017.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, HepG2, HeLa, MCF7, Mouse liver, Mouse spleen, Mouse thymus, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 471-720 of human ZNF408 (NP_079017.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PVCG RPLA NQGS LRNH MRLH TGEK PFLC PHCG RAFR QRGN LRGH LRLH TGER PYRC PHCA DAFP QLPE LRRH LISH TGEA HLCP VCGK ALRD PHTL RAHE RLHS GERP FPCP QCGR AYTL ATKL RRHL KSHL EDKP YRCP TCGM GYTL PQSL RRHQ LSHR PEAP CSPP SVPS AASE PTVV LLQA EPQL LDTH REEE VSPA RDVV EVTI SESQ EKCF VVPE EPDA APSL VLIH KDMG LGAW AEVV EVEM GT |
| Gene ID: | 79797 |
| Uniprot: | Q9H9D4 |
| Cellular Location: | Nucleus |
| Calculated MW: | 78kDa |
| Observed MW: | 78kDa |
| Synonyms: | ZNF408, EVR6, RP72 |
| Background: | The protein encoded by this gene contains ten tandem zinc fingers and an N-terminal SET domain, so it is likely a DNA binding protein that interacts with other proteins. In adults, the encoded protein is expressed most highly in retina. Consequently, defects in this gene have been associated with familial exudative vitreoretinopathy (FEVR) and retinitis pigmentosa (RP). |
| UniProt Protein Function: | ZNF408: May be involved in transcriptional regulation. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: nucleus Molecular Function:identical protein binding; protein binding Disease: Exudative Vitreoretinopathy 6; Retinitis Pigmentosa 72 |
| UniProt Code: | Q9H9D4 |
| NCBI GenInfo Identifier: | 17368963 |
| NCBI Gene ID: | 79797 |
| NCBI Accession: | Q9H9D4.1 |
| UniProt Related Accession: | Q9H9D4 |
| Molecular Weight: | 78,439 Da |
| NCBI Full Name: | Zinc finger protein 408 |
| NCBI Synonym Full Names: | zinc finger protein 408 |
| NCBI Official Symbol: | ZNF408 |
| NCBI Official Synonym Symbols: | EVR6; RP72 |
| NCBI Protein Information: | zinc finger protein 408 |
| UniProt Protein Name: | Zinc finger protein 408 |
| UniProt Synonym Protein Names: | PR domain zinc finger protein 17 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZNF408 |
| UniProt Entry Name: | ZN408_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ZNF408 antibody (CAB8512) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded rat lung using ZNF408 antibody (CAB8512) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using ZNF408 antibody (CAB8512) at dilution of 1:100 (40x lens). |
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