Name: Anti-ZNF384 Antibody (CAB15964)
Brand: Epigenetics & Nuclear Signaling Antibodies 2
SKU: CAB15964
Availability: OutOfStock

Antibody Name:	Anti-ZNF384 Antibody
Antibody SKU:	CAB15964
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ZNF384 (NP_001035009.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, Mouse kidney, Mouse brain, Rat kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ZNF384 (NP_001035009.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MEES HFNS NPYF WPSI PTVS GQIE NTMF INKM KDQL LPEK GCGL APPH YPTL LTVP ASVS LPSG ISMD TESK SDQL TPHS QASV TQNI TVVP VPST GLMT AALQ VVPD LSKK VAST LTEE GGGG GGGG GSVA PKPP RGRK KKRM LESG LPEM NDPY VLSP EDDD DHQK DGKT YRCR MCSL
Gene ID:	171017
Uniprot:	Q8TF68
Cellular Location:	Nucleus
Calculated MW:	50kDa/56kDa/63kDa
Observed MW:	75kDa

Synonyms:

ZNF384, CAGH1, CAGH1A, CIZ, ERDA2, NMP4, NP, TNRC1

Background:

This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7.

UniProt Protein Function:	ZNF384: Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1. Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:C2H2-type zinc finger protein; DNA-binding Chromosomal Location of Human Ortholog: 12p12 Cellular Component: focal adhesion; nucleus Molecular Function:metal ion binding; sequence-specific DNA binding; SH3 domain binding Biological Process: nucleocytoplasmic transport; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
NCBI Summary:	This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]
UniProt Code:	Q8TF68
NCBI GenInfo Identifier:	296453052
NCBI Gene ID:	171017
NCBI Accession:	Q8TF68.2
UniProt Secondary Accession:	Q8TF68,O15407, Q7Z722, Q8N938,
UniProt Related Accession:	Q8TF68
Molecular Weight:	50,538 Da
NCBI Full Name:	Zinc finger protein 384
NCBI Synonym Full Names:	zinc finger protein 384
NCBI Official Symbol:	ZNF384
NCBI Official Synonym Symbols:	NP; CIZ; NMP4; CAGH1; ERDA2; TNRC1; CAGH1A
NCBI Protein Information:	zinc finger protein 384
UniProt Protein Name:	Zinc finger protein 384
UniProt Synonym Protein Names:	CAG repeat protein 1; CAS-interacting zinc finger protein; Nuclear matrix transcription factor 4; Nuclear matrix protein 4; Trinucleotide repeat-containing gene 1 protein
Protein Family:	Zinc finger protein
UniProt Gene Name:	ZNF384
UniProt Entry Name:	ZN384_HUMAN

Western blot analysis of extracts of various cell lines, using ZNF384 antibody (CAB15964) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

ZNF384 Antibody (PACO02198)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)