Cell Biology Antibodies 11
Anti-ZNF346 Antibody (CAB7507)
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- SKU:
- CAB7507
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ZNF346 Antibody |
| Antibody SKU: | CAB7507 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-294 of human ZNF346 (NP_036411.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, MCF7, THP-1, HeLa, Mouse testis, Mouse heart, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-294 of human ZNF346 (NP_036411.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEYP APAT VQAA DGGA AGPY SSSE LLEG QEPD GVRF DRER ARRL WEAV SGAQ PVGR EEVE HMIQ KNQC LFTN TQCK VCCA LLIS ESQK LAHY QSKK HANK VKRY LAIH GMET LKGE TKKL DSDQ KSSR SKDK NQCC PICN MTFS SPVV AQSH YLGK THAK NLKL KQQS TKVE ALHQ NREM IDPD KFCS LCHA TFND PVMA QQHY VGKK HRKQ ETKL KLMA RYGR LADP AVTD FPAG KGYP CKTC KIVL NSIE QYQA HVSG FKHK NQSP KTVA SSLG QIPM QRQP IQKD STTL ED |
| Gene ID: | 23567 |
| Uniprot: | Q9UL40 |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus |
| Calculated MW: | 29kDa/32kDa/35kDa |
| Observed MW: | 33-38kDa |
| Synonyms: | ZNF346, JAZ, Zfp346 |
| Background: | The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | ZNF346: Binds to dsRNA and DNA. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 5q35.2 Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; enzyme binding; zinc ion binding; double-stranded RNA binding Biological Process: positive regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UL40 |
| NCBI GenInfo Identifier: | 74735051 |
| NCBI Gene ID: | 23567 |
| NCBI Accession: | Q9UL40.1 |
| UniProt Secondary Accession: | Q9UL40,Q68CV9, Q6ZMW1, B7Z367, |
| UniProt Related Accession: | Q9UL40 |
| Molecular Weight: | 294 |
| NCBI Full Name: | Zinc finger protein 346 |
| NCBI Synonym Full Names: | zinc finger protein 346 |
| NCBI Official Symbol: | ZNF346 |
| NCBI Official Synonym Symbols: | JAZ; Zfp346 |
| NCBI Protein Information: | zinc finger protein 346; just another zinc finger protein; double-stranded RNA-binding zinc finger protein JAZ |
| UniProt Protein Name: | Zinc finger protein 346 |
| UniProt Synonym Protein Names: | Just another zinc finger protein |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZNF346 |
| UniProt Entry Name: | ZN346_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ZNF346 antibody (CAB7507) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using ZNF346 antibody (CAB7507) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A549 cells using ZNF346 antibody (CAB7507). Blue: DAPI for nuclear staining. |
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