Epigenetics & Nuclear Signaling Antibodies 4

Anti-ZNF148 Antibody (CAB7001)

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SKU:
CAB7001
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ZNF148 Antibody
Antibody SKU:CAB7001
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 690-794 of human ZNF148 (NP_068799.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:20 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 690-794 of human ZNF148 (NP_068799.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SGDE TNHA SATS TQDF LDQV TSQK KAEA QPVH QAYQ MSSF EQPF RAPY HGSR AGIA TQFS TANG QVNL RGPG TSAE FSEF PLVN VNDN RAGM TSSP DATT GQTF G
Gene ID:7707
Uniprot:Q9UQR1
Cellular Location:Nucleus
Calculated MW:14kDa/88kDa
Observed MW:105kDa
Synonyms:ZNF148, BERF-1, BFCOL1, GDACCF, HT-BETA, ZBP-89, ZFP148, pHZ-52
Background:The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies.
UniProt Protein Function:ZNF148: a transcription factor. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: Golgi apparatus; nucleoplasm

Molecular Function:protein binding; sequence-specific DNA binding

Biological Process: cellular defense response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; substantia nigra development; transcription from RNA polymerase II promoter

UniProt Code:Q9UQR1
NCBI GenInfo Identifier:12643385
NCBI Gene ID:7707
NCBI Accession:Q9UQR1.2
UniProt Secondary Accession:Q9UQR1,O00389, O43591, Q58EY5, Q6PJ98, D3DN27,
UniProt Related Accession:Q9UQR1
Molecular Weight:14,473 Da
NCBI Full Name:Zinc finger protein 148
NCBI Synonym Full Names:zinc finger protein 148
NCBI Official Symbol:ZNF148  
NCBI Official Synonym Symbols:BERF-1; BFCOL1; ZBP-89; ZFP148; pHZ-52; HT-BETA  
NCBI Protein Information:zinc finger protein 148
UniProt Protein Name:Zinc finger protein 148
UniProt Synonym Protein Names:Transcription factor ZBP-89; Zinc finger DNA-binding protein 89
Protein Family:Zinc finger protein
UniProt Gene Name:ZNF148  
UniProt Entry Name:ZN148_HUMAN
Anti-ZNF148 Antibody (CAB7001)Western blot analysis of extracts of various cell lines, using ZNF148 Antibody (CAB7001) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-ZNF148 Antibody (CAB7001)Immunohistochemistry of paraffin-embedded rat lung using ZNF148 antibody (CAB7001) at dilution of 1:100 (40x lens).
Anti-ZNF148 Antibody (CAB7001)Immunohistochemistry of paraffin-embedded rat liver using ZNF148 antibody (CAB7001) at dilution of 1:100 (40x lens).
Anti-ZNF148 Antibody (CAB7001)Immunohistochemistry of paraffin-embedded rat brain using ZNF148 antibody (CAB7001) at dilution of 1:100 (40x lens).
Anti-ZNF148 Antibody (CAB7001)Immunohistochemistry of paraffin-embedded rat heart using ZNF148 antibody (CAB7001) at dilution of 1:100 (40x lens).
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