Epigenetics & Nuclear Signaling Antibodies 1

Anti-ZMYM3 Antibody (CAB12990)

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SKU:
CAB12990
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ZMYM3 Antibody
Antibody SKU:CAB12990
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-300 of human ZMYM3 (NP_001164634.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-300 of human ZMYM3 (NP_001164634.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLEP LAPD SPIT LQSP HIEE EETT SIAT ARRG SPGQ EEEL PQGQ PQSP NAPP SPSV GETL GDGI NSSQ TKPG GSSP PAHP SLPG DGLT AKAS EKPP ERKR SERV RRAE PPKP EVVD STES IPVS DEDS DAMV DDPN DEDF VPFR PRRS PRMS LRSS VSQR A
Gene ID:9203
Uniprot:Q14202
Cellular Location:Nucleus
Calculated MW:52kDa/151kDa/152kDa
Observed MW:152kDa
Synonyms:ZMYM3, DXS6673E, MYM, XFIM, ZNF198L2, ZNF261
Background:This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation. Several alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:ZNF261: Plays a role in the regulation of cell morphology and cytoskeletal organization. A chromosomal aberration involving ZMYM3 may be a cause of X-linked mental retardation in Xq13.1. Translocation t(X;13)(q13.1;?). 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: nucleus

Molecular Function:DNA binding; zinc ion binding

Biological Process: multicellular organismal development; regulation of cell morphogenesis; cytoskeleton organization and biogenesis

UniProt Code:Q14202
NCBI GenInfo Identifier:283837896
NCBI Gene ID:9203
NCBI Accession:NP_001164634.1
UniProt Secondary Accession:Q14202,O15089, Q96E26, D3DVV3,
UniProt Related Accession:Q14202
Molecular Weight:152,379 Da
NCBI Full Name:zinc finger MYM-type protein 3 isoform 3
NCBI Synonym Full Names:zinc finger, MYM-type 3
NCBI Official Symbol:ZMYM3  
NCBI Official Synonym Symbols:MYM; XFIM; ZNF261; DXS6673E; ZNF198L2  
NCBI Protein Information:zinc finger MYM-type protein 3; zinc finger protein 261
UniProt Protein Name:Zinc finger MYM-type protein 3
UniProt Synonym Protein Names:Zinc finger protein 261
Protein Family:Zinc finger MYM-type protein
UniProt Gene Name:ZMYM3  
UniProt Entry Name:ZMYM3_HUMAN
Anti-ZMYM3 Antibody (CAB12990)Western blot analysis of extracts of HeLa cells, using ZMYM3 antibody (CAB12990) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-ZMYM3 Antibody (CAB12990)Immunohistochemistry of paraffin-embedded human tonsil using ZMYM3 antibody (CAB12990) at dilution of 1:100 (40x lens).
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