Epigenetics & Nuclear Signaling Antibodies 3

Anti-ZMIZ2 Antibody (CAB17301)

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SKU:
CAB17301
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ZMIZ2 Antibody
Antibody SKU:CAB17301
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human ZMIZ2 (NP_001287888).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Jurkat, HeLa, 293T, mouse brain, rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human ZMIZ2 (NP_001287888).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNSM NPMK PALP PAPH GDGS FAYE SVPW QQSA TQPA GSLS VVTT VWGV GNAT QSQC LGQQ AFAE GGAN KGYV QQGV YSRG GYPG APGF TTGY AGGP GGLG LPSH AARP ST
Gene ID:83637
Uniprot:Q8NF64
Cellular Location:
Calculated MW:
Observed MW:115kDa
Synonyms:ZMIZ2, NET27, TRAFIP20, ZIMP7, hZIMP7
Background:ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).
UniProt Protein Function:ZIMP7: Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: nucleoplasm; mitochondrion; nuclear replication fork; nucleus

Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity; zinc ion binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
UniProt Code:Q8NF64
NCBI GenInfo Identifier:54607108
NCBI Gene ID:83637
NCBI Accession:NP_113637.3
UniProt Secondary Accession:Q8NF64,O94790, Q0VGB4, Q659A8, Q6JKL5, Q8WTX8, Q96Q01 Q9BQH7, A4D2K7, D3DVL1,
UniProt Related Accession:Q8NF64
Molecular Weight:96,537 Da
NCBI Full Name:zinc finger MIZ domain-containing protein 2 isoform 1
NCBI Synonym Full Names:zinc finger, MIZ-type containing 2
NCBI Official Symbol:ZMIZ2  
NCBI Official Synonym Symbols:NET27; ZIMP7; hZIMP7; TRAFIP20  
NCBI Protein Information:zinc finger MIZ domain-containing protein 2; PIAS-like protein Zimp7
UniProt Protein Name:Zinc finger MIZ domain-containing protein 2
UniProt Synonym Protein Names:PIAS-like protein Zimp7
Protein Family:Zinc finger MIZ domain-containing protein
UniProt Gene Name:ZMIZ2  
UniProt Entry Name:ZMIZ2_HUMAN
Anti-ZMIZ2 Antibody (CAB17301)Western blot analysis of extracts of various cell lines, using ZMIZ2 antibody (CAB17301) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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