Signal Transduction Antibodies 1

Anti-ZIP14 Antibody (CAB10413)

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SKU:
CAB10413
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ZIP14 Antibody
Antibody SKU:CAB10413
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-340 of human ZIP14 (NP_001128626.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:LO2, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-340 of human ZIP14 (NP_001128626.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ILKI LLKQ KNEH HHGH SHYA SESL PSKK DQEE GVME KLQN GDLD HMIP QHCS SELD GKAP MVDE KVIV GSLS VQDL QASQ SACY WLKG VRYS DIGT LAWM I
Gene ID:23516
Uniprot:Q15043
Cellular Location:Cell membrane, Cell projection, Multi-pass membrane protein, lamellipodium
Calculated MW:52kDa/54kDa
Observed MW:50kDa
Synonyms:SLC39A14, HMNDYT2, LZT-Hs4, NET34, ZIP14, cig19
Background:
UniProt Protein Function:SLC39A14: May mediate cellular uptake of nontransferrin-bound iron. Broad-scope metal ion transporter with a preference for zinc uptake. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytoplasm; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:zinc ion transmembrane transporter activity

Biological Process: cellular zinc ion homeostasis

Disease: Hypermanganesemia With Dystonia 2

NCBI Summary:Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
UniProt Code:Q15043
NCBI GenInfo Identifier:313104191
NCBI Gene ID:23516
NCBI Accession:Q15043.3
UniProt Secondary Accession:Q15043,Q6ZME8, Q96BB3, A6NH98, B4DIW3, B6EU88, D3DSR4
UniProt Related Accession:Q15043
Molecular Weight:54kDa
NCBI Full Name:Zinc transporter ZIP14
NCBI Synonym Full Names:solute carrier family 39 member 14
NCBI Official Symbol:SLC39A14  
NCBI Official Synonym Symbols:NET34; ZIP14; cig19; HMNDYT2; LZT-Hs4  
NCBI Protein Information:zinc transporter ZIP14
UniProt Protein Name:Zinc transporter ZIP14
UniProt Synonym Protein Names:LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Solute carrier family 39 member 14; Zrt- and Irt-like protein 14; ZIP-14
Protein Family:Zinc transporter
UniProt Gene Name:SLC39A14  
Anti-ZIP14 Antibody (CAB10413)Western blot analysis of extracts of various cell lines, using ZIP14 antibody (CAB10413) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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