Signal Transduction Antibodies 2

Anti-Zip12 Antibody (CAB16006)

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SKU:
CAB16006
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-Zip12 Antibody
Antibody SKU:CAB16006
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC39A12 (NP_001138667.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, mouse brain, mouse eye, mouse lung, rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC39A12 (NP_001138667.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MCFR TKLS VSWV PLFL LLSR VFST ETDK PSAQ DSRS RGSS GQPA DLLQ VLSA GDHP PHNH SRSL IKTL LEKT GCPR RRNG MQGD CNLC FEPD ALLL IAGG
Gene ID:221074
Uniprot:Q504Y0
Cellular Location:
Calculated MW:45kDa/61kDa/72kDa/76kDa
Observed MW:77kDa
Synonyms:SLC39A12, LZT-Hs8, ZIP-12, bA570F3.1, Zip12
Background:Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).
UniProt Protein Function:SLC39A12: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia. Belongs to the ZIP transporter (TC 2.A.5) family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p12.33

Cellular Component: perinuclear region of cytoplasm; integral to membrane; plasma membrane; vesicle

Molecular Function:zinc ion transmembrane transporter activity

Biological Process: signal transduction; regulation of microtubule polymerization

NCBI Summary:Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]
UniProt Code:Q504Y0
NCBI GenInfo Identifier:223633939
NCBI Gene ID:221074
NCBI Accession:NP_001138667
UniProt Related Accession:Q504Y0
Molecular Weight:45kDa; 61kDa; 72kDa; 76kDa
NCBI Full Name:zinc transporter ZIP12 isoform 1
NCBI Synonym Full Names:solute carrier family 39 member 12
NCBI Official Symbol:SLC39A12  
NCBI Official Synonym Symbols:ZIP-12; LZT-Hs8; bA570F3.1  
NCBI Protein Information:zinc transporter ZIP12
UniProt Protein Name:Zinc transporter ZIP12
UniProt Synonym Protein Names:LIV-1 subfamily of ZIP zinc transporter 8; LZT-Hs8; Solute carrier family 39 member 12; Zrt- and Irt-like protein 12; ZIP-12
Protein Family:Probable zinc transporter
UniProt Gene Name:SLC39A12  
UniProt Entry Name:S39AC_HUMAN
Anti-Zip12 Antibody (CAB16006)Western blot analysis of extracts of various cell lines, using Zip12 antibody (CAB16006) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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