Developmental Biology

Anti-ZIC2 Antibody (CAB15736)

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SKU:
CAB15736
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-ZIC2 Antibody
Antibody SKU:CAB15736
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ZIC2 (NP_009060.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ZIC2 (NP_009060.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLLD AGPQ FPAI GVGS FARH HHHS AAAA AAAA AEMQ DREL SLAA AQNG FVDS AAAH MGAF KLNP GAHE LSPG QSSA FTSQ GPGA YPGS AAAA AAAA ALGP HAAH VGSY SGPP FNST RDFL FRSR GFGD SAPG GGQH GLFG PGAG GLHH AHSD AQGH LLFP GLPE QHGP HGSQ NVLN GQMR LGLP GEVF GRSE QYRQ VASP RTDP YSAA QLHN QYGP MNMN
Gene ID:7546
Uniprot:O95409
Cellular Location:Cytoplasm, Nucleus
Calculated MW:55kDa
Observed MW:50kDa
Synonyms:ZIC2, HPE5
Background:This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
NCBI Summary:This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
UniProt Code:O95409
NCBI GenInfo Identifier:22547182
NCBI Gene ID:7545
NCBI Accession:NP_003403.2
UniProt Secondary Accession:O95409,O95409, O60481,
UniProt Related Accession:Q15915
Molecular Weight:
NCBI Full Name:zinc finger protein ZIC 1
NCBI Synonym Full Names:Zic family member 1
NCBI Official Symbol:ZIC1  
NCBI Official Synonym Symbols:ZIC; CRS6; ZNF201  
NCBI Protein Information:zinc finger protein ZIC 1
UniProt Protein Name:Zinc finger protein ZIC 1
UniProt Synonym Protein Names:Zinc finger protein 201; Zinc finger protein of the cerebellum 1
UniProt Gene Name:ZIC1  
UniProt Entry Name:ZIC1_HUMAN
Anti-ZIC2 Antibody (CAB15736)Western blot analysis of extracts of various cell lines, using ZIC2 antibody (CAB15736) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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