Cell Biology Antibodies 13
Anti-ZIC1 Antibody (CAB17547)
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- SKU:
- CAB17547
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ZIC1 Antibody |
| Antibody SKU: | CAB17547 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human ZIC1 (NP_003403.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, U-251MG, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human ZIC1 (NP_003403.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LFAA SAGG FGGP HGHT DAAG HLLF PGLH EQAA GHAS PNVV NGQM RLGF SGDM YPRP EQYG QVTS PRSE HYAA PQLH GYGP MNVN MAAH HGA |
| Gene ID: | 7545 |
| Uniprot: | Q15915 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 48kDa |
 | Western blot - ZIC1 Polyclonal Antibody (CAB17547) |
| Synonyms: | CRS6, ZIC, ZNF201, ZIC1 |
| Background: | This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ZIC1: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3'. Belongs to the GLI C2H2-type zinc-finger protein family. |
| UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 3q24 Cellular Component: nucleoplasm; nucleus Molecular Function:transcription factor activity Biological Process: brain development; inner ear morphogenesis; pattern specification process; positive regulation of protein import into nucleus; positive regulation of transcription, DNA-dependent; regulation of smoothened signaling pathway Disease: Craniosynostosis 6 |
| NCBI Summary: | This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15915 |
| NCBI GenInfo Identifier: | 209572702 |
| NCBI Gene ID: | 7545 |
| NCBI Accession: | Q15915.2 |
| UniProt Secondary Accession: | Q15915,Q2M3N1, |
| UniProt Related Accession: | Q15915 |
| Molecular Weight: | 48,309 Da |
| NCBI Full Name: | Zinc finger protein ZIC 1 |
| NCBI Synonym Full Names: | Zic family member 1 |
| NCBI Official Symbol: | ZIC1 |
| NCBI Official Synonym Symbols: | ZIC; CRS6; ZNF201 |
| NCBI Protein Information: | zinc finger protein ZIC 1 |
| UniProt Protein Name: | Zinc finger protein ZIC 1 |
| UniProt Synonym Protein Names: | Zinc finger protein 201; Zinc finger protein of the cerebellum 1 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZIC1 |
| UniProt Entry Name: | ZIC1_HUMAN |
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